Synonyms: 2,4-Dihydroxypyrimidine, Pyrimidine-2,4(1H,3H)-dione  

CAS No: 66-22-8  

Molecular Formula: C₄H₄N₂O₂  

Molecular Weight: 112.09 g/mol  

Structure:  

Physical and Chemical Properties

Appearance: White to off-white crystalline powder .  

-Melting Point: >300 °C (lit.).  

- Boiling Point: 209.98°C (estimate).  

- Solubility:  

  - Soluble in hot water (3600 mg/L at 25°C).  

  - Slightly soluble in cold water, ethanol, and ether; soluble in alkaline solutions.  

- Density: 1.4421 (estimate).  

- pKa: 9.45 (at 25°C).  

- Stability: Stable under recommended storage conditions. Incompatible with strong oxidizing agents and humidity.  

Purity & Specifications  

- Purity: ≥99% (HPLC).  

- Impurities**: May contain trace amounts of related pyrimidine derivatives.  

Storage and Handling

- Storage Conditions:  

- Store in a cool, dry place (15–30°C), protected from light and moisture.  

- Long-term stability: Up to 2 years when unopened.  

- Handling Precautions:  

  - Wear lab coat and gloves. Avoid inhalation or direct contact.  

  - For research use only. Not intended for diagnostic or therapeutic applications.  

 Applications  

1. Molecular Biology: A key component of RNA, pairing with adenine during transcription.  

2. Pharmaceutical Intermediates: Used in synthesis of antiviral and anticancer drugs (e.g., 5-fluorouracil).  

3. Biochemical Research: Applied in studies of nucleic acid metabolism, enzyme inhibition, and oxidative stress.  

Packaging Specifications  

- Standard Packaging:  

- 25 kg/drum (industrial grade).  

- 1 g, 5 g, 25 g, 100 g (research grade).  

- Customization: Available upon request (e.g., bulk orders or specific purity levels).  

Safety Information (MSDS Highlights)

- Hazard Statements: Non-hazardous under normal use.  

- First Aid Measures:  

- Skin contact: Wash with soap and water.  

- Eye contact: Rinse thoroughly with water.  

- Disposal: Follow local regulations for chemical waste.  

 References  

-Analytical Data: PubChem ID 1174, Reaxys RN 606623.  

- Regulatory Compliance: EINECS 200-621-9; Merck Index 9850.  

Note: For detailed experimental protocols and batch-specific COA (Certificate of Analysis), please contact the supplier or refer to the original manufacturer’s documentation.